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OBJECTIVE: Gliomatosis cerebri is an enigmatic diffuse brain neoplasm whose prognosis is grim. We reviewed data for patients with gliomatosis who were treated at the University of California, San Francisco, during a 10-year period. Our focus was on presentation, radiological and pathological features, and outcomes.

METHODS: We reviewed hospital and clinic records and magnetic resonance imaging scans for 22 patients with gliomatosis. The diagnosis was based on magnetic resonance imaging findings and tissue confirmation for all patients. Seven patients also underwent magnetic resonance spectroscopy. Eleven patients were male (50%), and the median age at presentation was 49 years (range, 7–79 yr).

RESULTS: Kaplan-Meier analysis demonstrated median lengths of survival as follows: no treatment, 1 month (n= 4); radiotherapy alone, 28 months (95% confidence interval, 5–51 mo; n= 13 …