作者
Lee Hogarth, Bernard W Balleine, Laura H Corbit, Simon Killcross
发表日期
2013/4
来源
Annals of the New York Academy of Sciences
卷号
1282
期号
1
页码范围
12-24
简介
Learning theory proposes that drug seeking is a synthesis of multiple controllers. Whereas goal‐directed drug seeking is determined by the anticipated incentive value of the drug, habitual drug seeking is elicited by stimuli that have formed a direct association with the response. Moreover, drug‐paired stimuli can transfer control over separately trained drug seeking responses by retrieving an expectation of the drug's identity (specific transfer) or incentive value (general transfer). This review covers outcome devaluation and transfer of stimulus‐control procedures in humans and animals, which isolate the differential governance of drug seeking by these four controllers following various degrees of contingent and noncontingent drug exposure. The neural mechanisms underpinning these four controllers are also reviewed. These studies suggest that although initial drug seeking is goal‐directed, chronic drug exposure …
引用总数
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学术搜索中的文章
L Hogarth, BW Balleine, LH Corbit, S Killcross - Annals of the New York Academy of Sciences, 2013