作者
Wenxin Wan, Susan Peters, Lützen Portengen, Ann Olsson, Joachim Schüz, Wolfgang Ahrens, Miriam Schejbalova, Paolo Boffetta, Thomas Behrens, Thomas Brüning, Benjamin Kendzia, Dario Consonni, Paul A Demers, Eleonóra Fabiánová, Guillermo Fernández-Tardón, John K Field, Francesco Forastiere, Lenka Foretova, Pascal Guénel, Per Gustavsson, Karl-Heinz Jöckel, Stefan Karrasch, Maria Teresa Landi, Jolanta Lissowska, Christine Barul, Dana Mates, John R McLaughlin, Franco Merletti, Enrica Migliore, Lorenzo Richiardi, Tamás Pándics, Hermann Pohlabeln, Jack Siemiatycki, Beata Świątkowska, Heinz-Erich Wichmann, David Zaridze, Calvin Ge, Kurt Straif, Hans Kromhout, Roel Vermeulen
发表日期
2024/1/15
期刊
American journal of respiratory and critical care medicine
卷号
209
期号
2
页码范围
185-196
出版商
American Thoracic Society
简介
Rationale: Benzene has been classified as carcinogenic to humans, but there is limited evidence linking benzene exposure to lung cancer.
Objectives: We aimed to examine the relationship between occupational benzene exposure and lung cancer.
Methods: Subjects from 14 case-control studies across Europe and Canada were pooled. We used a quantitative job-exposure matrix to estimate benzene exposure. Logistic regression models assessed lung cancer risk across different exposure indices. We adjusted for smoking and five main occupational lung carcinogens and stratified analyses by smoking status and lung cancer subtypes.
Measurements and Main Results: Analyses included 28,048 subjects (12,329 cases, 15,719 control subjects). Lung cancer odds ratios ranged from 1.12 (95% confidence interval, 1.03–1.22) to 1.32 (95% confidence interval, 1.18–1.48) (Ptrend = 0.002) for groups with the lowest …
学术搜索中的文章
W Wan, S Peters, L Portengen, A Olsson, J Schüz… - American journal of respiratory and critical care …, 2024