作者
Katrina M Babilonia, Larry K Golightly, Jonathan A Gutman, Kathryn L Hassell, Jeffrey N Kaiser, Tyree H Kiser, Patrick M Klem, Toby C Trujillo
发表日期
2014/11
期刊
Clinical and Applied Thrombosis/Hemostasis
卷号
20
期号
8
页码范围
799-806
出版商
SAGE Publications
简介
Background
Guidelines are discordant concerning management of patients having thrombocytopenia with cancer-associated thrombosis (CAT).
Methods
Hospitalized adults with CAT and platelets ≤50 × 109 cells/L were managed with dalteparin 100 units/kg subcutaneously once daily. Comparator patients with CAT and platelets >50 × 109 cells/L were managed with dalteparin 200 units/kg/d.
Results
Outcomes of 35 patients with thrombocytopenia (mean platelet count 26 ± 8.3 × 109 cells/L) and 58 comparator patients (mean platelet count 155 ± 75 × 109 cells/L) were evaluated. In all, 2 (5.7%) patients in the thrombocytopenia group and 1 patient (1.9%) in the comparator group experienced new-onset venous thromboembolism (odds ratio 3.31, 95% confidence interval [CI] 0.29-37.90, P = .556). The incidence of bleeding in patients with thrombocytopenia (8.6%) was similar to that in comparator patients (9.4%; risk …
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KM Babilonia, LK Golightly, JA Gutman, KL Hassell… - Clinical and Applied Thrombosis/Hemostasis, 2014