作者
Hans Kristian Moen Vollan, Oscar M Rueda, Suet-Feung Chin, Christina Curtis, Gulisa Turashvili, Sohrab Shah, Ole Christian Lingjaerde, Yinyin Yuan, Charlotte K Ng, Mark J Dunning, Ed Dicks, Elena Provenzano, Stephen Sammut, Steven McKinney, Ian O Ellis, Sarah Pinder, Arnie Purushotham, Leigh C Murphy, Vessela N Kristensen, James D Brenton, Paul DP Pharoah, Anne-Lise Børresen-Dale, Samuel Aparicio, Carlos Caldas, METABRIC Group
发表日期
2015/1/1
期刊
Molecular oncology
卷号
9
期号
1
页码范围
115-127
出版商
No longer published by Elsevier
简介
Complex focal chromosomal rearrangements in cancer genomes, also called “firestorms”, can be scored from DNA copy number data. The complex arm-wise aberration index (CAAI) is a score that captures DNA copy number alterations that appear as focal complex events in tumors, and has potential prognostic value in breast cancer. This study aimed to validate this DNA-based prognostic index in breast cancer and test for the first time its potential prognostic value in ovarian cancer. Copy number alteration (CNA) data from 1950 breast carcinomas (METABRIC cohort) and 508 high-grade serous ovarian carcinomas (TCGA dataset) were analyzed. Cases were classified as CAAI positive if at least one complex focal event was scored. Complex alterations were frequently localized on chromosome 8p (n = 159), 17q (n = 176) and 11q (n = 251). CAAI events on 11q were most frequent in estrogen receptor positive …
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HKM Vollan, OM Rueda, SF Chin, C Curtis… - Molecular oncology, 2015