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Background: Depression is one of the most common neuropsychiatric disorders among ischemic stroke survivors, affecting up to 50%. Beta-blockers (BB) are commonly prescribed for stroke patients and the evidence for an association between BB use and depression is mixed. We explored this relationship in an urban, predominantly Afro-Caribbean stroke cohort.

Hypothesis: The use of BB will be associated with an increase in frequency and severity of post-stroke depression.

Methods: Observational, cross-sectional, prospective study of eligible non-demented patients with ischemic stroke in the past 3 years and without a history of major depression. Subjects were recruited from the inpatient stroke unit, outpatient stroke clinics (including at Kings County Hospital), and inpatient rehabilitation unit at SUNY Downstate Medical Center. Demographics, medical history, and current medications were recorded from …