作者
Alessandro Gialluisi, Dianne F Newbury, Erik G Wilcutt, Richard K Olson, John C DeFries, William M Brandler, Bruce F Pennington, Shelley D Smith, Thomas S Scerri, Nuala H Simpson, SLI Consortium, M Luciano, DM Evans, TC Bates, JF Stein, JB Talcott, AP Monaco, S Paracchini, C Francks, SE Fisher
发表日期
2014/9
期刊
Genes, Brain and Behavior
卷号
13
期号
7
页码范围
686-701
出版商
Blackwell Publishing Ltd
简介
Reading and language abilities are heritable traits that are likely to share some genetic influences with each other. To identify pleiotropic genetic variants affecting these traits, we first performed a genome‐wide association scan (GWAS) meta‐analysis using three richly characterized datasets comprising individuals with histories of reading or language problems, and their siblings. GWAS was performed in a total of 1862 participants using the first principal component computed from several quantitative measures of reading‐ and language‐related abilities, both before and after adjustment for performance IQ. We identified novel suggestive associations at the SNPs rs59197085 and rs5995177 (uncorrected P ≈ 10–7 for each SNP), located respectively at the CCDC136/FLNC and RBFOX2 genes. Each of these SNPs then showed evidence for effects across multiple reading and language traits in univariate …
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A Gialluisi, DF Newbury, EG Wilcutt, RK Olson… - Genes, Brain and Behavior, 2014