作者
Bolun Ai, Xiangyi Kong, Xiangyu Wang, Kai Zhang, Xue Yang, Jie Zhai, Ran Gao, Yihang Qi, Jing Wang, Zhongzhao Wang, Yi Fang
发表日期
2019/6/26
期刊
Cell death & disease
卷号
10
期号
7
页码范围
502
出版商
Nature Publishing Group UK
简介
Previously, several protein-coding tumor suppressors localized at 1p36 have been reported. In the present work, we focus on functional long non-coding RNAs (lncRNAs) embedded in this locus. Small interfering RNA was used to identify lncRNA candidates with growth-suppressive activities in breast cancer. The mechanism involved was also explored. LINC01355 were downregulated in breast cancer cells relative to non-malignant breast epithelial cells. Overexpression of LINC01355 significantly inhibited proliferation, colony formation, and tumorigenesis of breast cancer cells. LINC01355 arrested breast cancer cells at the G0/G1 phase by repressing CCND1. Moreover, LINC01355 interacted with and stabilized FOXO3 protein, leading to transcriptional repression of CCND1. Importantly, LINC01355-mediated suppression of breast cancer growth was reversed by knockdown of FOXO3 or overexpression of …
学术搜索中的文章
LINC01355 suppresses breast cancer growth through FOXO3-mediated transcriptional repression of CCND1
B Ai, X Kong, X Wang, K Zhang, X Yang, J Zhai, R Gao… - Cell death & disease, 2019