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Premix membrane emulsification (ME) has been used to produce mono-disperse emulsions under process conditions that reduce the mechanical stress of sensitive compounds such as proteins, which can increase the stability of encapsulated biocompounds, but can cause membrane fouling. An organic nylon microfiltration membrane used to produce stable oil/water (O/W) emulsions stabilized with whey protein has been cleaned with different concentrations of commercial cleaning agents (Derquim+, Tween 20, or sodium hydroxide) alone or in combination, under different operation modes, including circulating the agent in forward or backwash mode. The efficiency of the membrane cleaning process was assessed using water flux recovery, membrane surface characterization by attenuated total reflectance infrared microspectroscopy (ATR-IRMS) and by assessing the performance of the cleaned membrane in …