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Oxytocin modulates human social interactions, and over the last decades many studies aimed to describe its effects for its potential involvement in the etiology of mental disorders. The resulting large body of evidence failed to converge in support of the initial prosocial hypothesis of oxytocin, and, consequently, novel hypotheses were developed like the social salience and approach-withdrawal hypotheses. To test them we carried a double-blind, placebo-controlled, between-subjects design study with intranasal administration of oxytocin where 62 participants free-viewed 16 short clips of social interactions varying in arousal (high vs. low) and valence (positive vs. negative) while continuously recording their eye-gaze. Four short clips of landscapes were used as a neutral condition. From participants’ eye gaze we computed GLIMPSE (gaze’s spatio-temporal consistency from multiple observers) to obtain a spatio …