作者
Federica Fregonese, Intira J Collins, Gonzague Jourdain, Sophie LeCoeur, Tim R Cressey, Nicole Ngo-Giang-Houng, Sukit Banchongkit, Apichat Chutanunta, Malee Techapornroong, Marc Lallemant
发表日期
2012/5/1
期刊
JAIDS Journal of Acquired Immune Deficiency Syndromes
卷号
60
期号
1
页码范围
91-98
出版商
LWW
简介
Objective:
To estimate the early and long-term mortalities and associated risk factors in adults receiving highly active antiretroviral therapy (HAART) in Thailand.
Design:
A prospective observational cohort study.
Methods:
Previously untreated adults starting HAART in 2002–2009 were followed-up in 43 public hospitals. Kaplan–Meier probability of survival was estimated up to 5 years of therapy. Factors associated with early (≤ 6 months) and long-term (> 6 months) mortalities were assessed using Cox regression analyses.
Results:
A total of 1578 adults received HAART (74% women; median age, 33 years; CD4 cell count, 124/mL), with a median follow-up of 50 months (interquartile range, 41–66). Eighty-nine patients (6%) died (37 occurred≤ 6 months and 52 occurred> 6 months) and 183 (12%) were lost to follow-up. Probability of survival [95% confidence interval (CI)] was 97.5%(96.7% to 98.2%) at 6 months, 96.6 …
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F Fregonese, IJ Collins, G Jourdain, S LeCoeur… - JAIDS Journal of Acquired Immune Deficiency …, 2012