作者
Sung-Yun Pai, Brent R Logan, Linda M Griffith, Rebecca H Buckley, Roberta E Parrott, Christopher C Dvorak, Neena Kapoor, Imelda C Hanson, Alexandra H Filipovich, Soma Jyonouchi, Kathleen E Sullivan, Trudy N Small, Lauri Burroughs, Suzanne Skoda-Smith, Ann E Haight, Audrey Grizzle, Michael A Pulsipher, Ka Wah Chan, Ramsay L Fuleihan, Elie Haddad, Brett Loechelt, Victor M Aquino, Alfred Gillio, Jeffrey Davis, Alan Knutsen, Angela R Smith, Theodore B Moore, Marlis L Schroeder, Frederick D Goldman, James A Connelly, Matthew H Porteus, Qun Xiang, William T Shearer, Thomas A Fleisher, Donald B Kohn, Jennifer M Puck, Luigi D Notarangelo, Morton J Cowan, Richard J O'Reilly
发表日期
2014/7/31
期刊
New England Journal of Medicine
卷号
371
期号
5
页码范围
434-446
出版商
Massachusetts Medical Society
简介
Background
The Primary Immune Deficiency Treatment Consortium was formed to analyze the results of hematopoietic-cell transplantation in children with severe combined immunodeficiency (SCID) and other primary immunodeficiencies. Factors associated with a good transplantation outcome need to be identified in order to design safer and more effective curative therapy, particularly for children with SCID diagnosed at birth.
Methods
We collected data retrospectively from 240 infants with SCID who had received transplants at 25 centers during a 10-year period (2000 through 2009).
Results
Survival at 5 years, freedom from immunoglobulin substitution, and CD3+ T-cell and IgA recovery were more likely among recipients of grafts from matched sibling donors than among recipients of grafts from alternative donors. However, the survival rate was high regardless of donor type among infants who received …
学术搜索中的文章
SY Pai, BR Logan, LM Griffith, RH Buckley, RE Parrott… - New England Journal of Medicine, 2014