作者
Andreas Fritsche, Matthias Axel Schweitzer, Hans-Ulrich Hring, 4001 Study Group*
发表日期
2003/6/17
期刊
Annals of internal medicine
卷号
138
期号
12
页码范围
952-959
出版商
American College of Physicians
简介
Background
Patients with type 2 diabetes are often treated with oral antidiabetic agents plus a basal insulin.
Objective
To investigate the efficacy and safety of glimepiride combined with either morning or bedtime insulin glargine or bedtime neutral protamine Hagedorn (NPH) insulin in patients with type 2 diabetes.
Design
Open-label, randomized, controlled trial.
Setting
111 centers in 13 European countries.
Patients
695 patients with type 2 diabetes who were previously treated with oral antidiabetic agents.
Intervention
Randomization to treatment with morning insulin glargine, bedtime NPH insulin, or bedtime insulin glargine for 24 weeks in addition to 3 mg of glimepiride. The insulin dose was titrated by using a predefined regimen to achieve …
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