作者
Peter J Castaldi, Adel Boueiz, Jeong Yun, Raul San Jose Estepar, James C Ross, George Washko, Michael H Cho, Craig P Hersh, Gregory L Kinney, Kendra A Young, Elizabeth A Regan, David A Lynch, Gerald J Criner, Jennifer G Dy, Stephen I Rennard, Richard Casaburi, Barry J Make, James Crapo, Edwin K Silverman, John E Hokanson, James D Crapo, Terri Beaty, Ferdouse Begum, Michael Cho, Dawn L DeMeo, Adel R Boueiz, Marilyn G Foreman, Eitan Halper-Stromberg, Lystra P Hayden, Jacqueline Hetmanski, Brian D Hobbs, Nan Laird, Christoph Lange, Sharon M Lutz, Merry-Lynn McDonald, Margaret M Parker, Dmitry Prokopenko, Dandi Qiao, Phuwanat Sakornsakolpat, Emily S Wan, Sungho Won, Juan Pablo Centeno, Jean-Paul Charbonnier, Harvey O Coxson, Craig J Galban, MeiLan K Han, Eric A Hoffman, Stephen Humphries, Francine L Jacobson, Philip F Judy, Ella A Kazerooni, Alex Kluiber, Pietro Nardelli, John D Newell Jr, Aleena Notary, Andrea Oh, Joyce Schroeder, Jered Sieren, Berend C Stoel, Juerg Tschirren, Edwin Van Beek, Bram van Ginneken, Eva van Rikxoort, Gonzalo Vegas Sanchez-Ferrero, Lucas Veitel, George R Washko, Carla G Wilson, Robert Jensen, Douglas Everett, Jim Crooks, Katherine Pratte, Matt Strand, Gregory Kinney, Surya P Bhatt, Jessica Bon, Alejandro A Diaz, Barry Make, Susan Murray, Elizabeth Regan, Xavier Soler, Russell P Bowler, Katerina Kechris, Farnoush Banaei-Kashani
发表日期
2020/5/1
来源
Chest
卷号
157
期号
5
页码范围
1147-1157
出版商
Elsevier
简介
COPD is a heterogeneous syndrome. Many COPD subtypes have been proposed, but there is not yet consensus on how many COPD subtypes there are and how they should be defined. The COPD Genetic Epidemiology Study (COPDGene), which has generated 10-year longitudinal chest imaging, spirometry, and molecular data, is a rich resource for relating COPD phenotypes to underlying genetic and molecular mechanisms. In this article, we place COPDGene clustering studies in context with other highly cited COPD clustering studies, and summarize the main COPD subtype findings from COPDGene. First, most manifestations of COPD occur along a continuum, which explains why continuous aspects of COPD or disease axes may be more accurate and reproducible than subtypes identified through clustering methods. Second, continuous COPD-related measures can be used to create subgroups through the …
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PJ Castaldi, A Boueiz, J Yun, RSJ Estepar, JC Ross… - Chest, 2020