作者
Eleanor M Dunican, Brett M Elicker, Travis Henry, David S Gierada, Mark L Schiebler, Wayne Anderson, Igor Barjaktarevic, R Graham Barr, Eugene R Bleecker, Richard C Boucher, Russell Bowler, Stephanie A Christenson, Alejandro Comellas, Christopher B Cooper, David Couper, Gerard J Criner, Mark Dransfield, Claire M Doerschuk, M Bradley Drummond, Nadia N Hansel, MeiLan K Han, Annette T Hastie, Eric A Hoffman, Jerry A Krishnan, Stephen C Lazarus, Fernando J Martinez, Charles E McCulloch, Wanda K O’Neal, Victor E Ortega, Robert Paine III, Stephen Peters, Joyce D Schroeder, Prescott G Woodruff, John V Fahy
发表日期
2021/4/15
期刊
American journal of respiratory and critical care medicine
卷号
203
期号
8
页码范围
957-968
出版商
American Thoracic Society
简介
Rationale: The relative roles of mucus plugs and emphysema in mechanisms of airflow limitation and hypoxemia in smokers with chronic obstructive pulmonary disease (COPD) are uncertain.
Objectives: To relate image-based measures of mucus plugs and emphysema to measures of airflow obstruction and oxygenation in patients with COPD.
Methods: We analyzed computed tomographic (CT) lung images and lung function in participants in the Subpopulations and Intermediate Outcome Measures in COPD Study. Radiologists scored mucus plugs on CT lung images, and imaging software automatically quantified emphysema percentage. Unadjusted and adjusted relationships between mucus plug score, emphysema percentage, and lung function were determined using regression.
Measurements and Main Results: Among 400 smokers, 229 (57%) had mucus plugs and 207 (52%) had emphysema, and …
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EM Dunican, BM Elicker, T Henry, DS Gierada… - American journal of respiratory and critical care …, 2021