作者
Michael J Eckert, Kartik Iyer, David R Euston, Masami Tatsuno
发表日期
2021/1/1
期刊
Learning & Memory
卷号
28
期号
1
页码范围
7-11
出版商
Cold Spring Harbor Lab
简介
Neocortical sleep spindles have been shown to occur more frequently following a memory task, suggesting that a method to increase spindle activity could improve memory processing. Stimulation of the neocortex can elicit a slow oscillation (SO) and a spindle, but the feasibility of this method to boost SO and spindles over time has not been tested. In rats with implanted neocortical electrodes, stimulation during slow wave sleep significantly increased SO and spindle rates compared to control rest periods before and after the stimulation session. Coordination between hippocampal sharp-wave ripples and spindles also increased. These effects were reproducible across five consecutive days of testing, demonstrating the viability of this method to increase SO and spindles.
引用总数
20212022202320241131
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