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Diindolylmethane (DIM), a bioactive compound rich in cruciferous vegetables, has been well known for its health benefits, including anticancer properties. However, its clinical utilization has been limited due to its low solubility, poor bioavailability, and high dosage requirements. The current study focuses on addressing these challenges by developing a self-nanoemulsifying drug delivery system (SNEDDS) for DIM to improve its delivery and therapeutic efficacy. Through careful optimization of various combinations of oils, surfactants, and co-surfactants, an ideal self-nanoemulsion formulation was achieved utilizing medium-chain triglyceride (MCT) oil, Tween 80, and PEG400 in a ratio of 20:60:20 (w/w/w), respectively. The resulting SNEDDS demonstrated favorable physicochemical properties, including stability and optimal particle size. The DIM-loaded SNEDDS (DIM-SNEDDS) exhibited a particle size of 17.99 ± 8 …