作者
Emmanuel C Patin, Sam Willcocks, Selinda Orr, Theresa H Ward, Roland Lang, Ulrich E Schaible
发表日期
2016/4
期刊
Innate immunity
卷号
22
期号
3
页码范围
181-185
出版商
SAGE Publications
简介
The role of macrophage-inducible C-type lectin (Mincle) in anti-inflammatory responses has not yet been fully characterized. Herein, we show that engagement of Mincle by trehalose-dimycolate or mycobacteria promotes IL-10 production in macrophages, which causes down-regulation of IL-12p40 secretion. Thus, Mincle mediates both pro- as well as anti-inflammatory responses.
学术搜索中的文章
EC Patin, S Willcocks, S Orr, TH Ward, R Lang… - Innate immunity, 2016