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To assess the effect of psychological distress on time to first pregnancy.

A follow-up study of time to pregnancy with prospective data on distress, with controlling for potential confounding variables.

Two university hospitals. Patient(s): Danish couples (n = 430) who were planning their first pregnancy and had no previous reproductive experience were followed for six menstrual cycles. Psychological distress was measured in each menstrual cycle by the General Health Questionnaire. Intervention(s): None. Main Outcome Measure(s): A clinically recognized pregnancy or a biochemical pregnancy detected in urine samples from each period of vaginal bleeding. Result(s): For cycles with the highest distress score (General Health Questionnaire score >80th percentile), the probability of conception per cycle was 12.8%, compared with 16.5% in other cycles (adjusted odds ratio [OR] 0.6; 95 …