作者
PC Donaghy, JT O'Brien, AJ Thomas
发表日期
2015/1
来源
Psychological Medicine
卷号
45
期号
2
页码范围
259-268
出版商
Cambridge University Press
简介
BackgroundThe clinical condition of dementia is now recognized as a diagnosis that can only be applied too late in the disease process to be useful for therapeutic approaches centring on disease modification. As a result, in recent years increasing attention has been given to mild cognitive impairment (MCI) and the diagnosis of prodromal dementia. This paper reviews the evidence for the clinical presentation of prodromal dementia with Lewy bodies (DLB).MethodA Medline search was carried out to identify articles with original data on the prodromal presentation of DLB.ResultsIn MCI cohorts that progress to dementia, the proportion diagnosed with DLB is similar to that reported in dementia cohorts. Prodromal DLB may present as any MCI subtype, although visuospatial and executive domains may be most commonly affected. Rapid eye movement (REM) sleep behaviour disorder (RBD), autonomic symptoms …
引用总数
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学术搜索中的文章
PC Donaghy, JT O'Brien, AJ Thomas - Psychological Medicine, 2015