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More than any other developmental period, adolescence has been characterized in the psychological and sociological literatures as fraught with struggles that are both intrapersonal and interpersonal in nature. Both the intrapersonal and interpersonal domains serve as sources of psychosocial stress during adolescence. Adolescence is a period in which relationships outside of the family multiply, take on new meanings, and deepen in intensity. Adolescent females appear to report more major interpersonal stress than males, and the relationship of major life stress with psychological symptoms may be stronger for adolescent females than males. Models of psychosocial stress that have emphasized intrapersonal factors and the cognitive appraisal processes of the individual can enrich and be enriched by our understanding of the social and interpersonal nature of stress. Understanding the meaning of a stressful …