作者
Sanne M Zinkstok, Mervyn DI Vergouwen, Stefan T Engelter, Philippe A Lyrer, Leo H Bonati, Marcel Arnold, Heinrich P Mattle, Urs Fischer, Hakan Sarikaya, Ralf W Baumgartner, Dimitrios Georgiadis, Céline Odier, Patrik Michel, Jukka Putaala, Martin Griebe, Nils Wahlgren, Niaz Ahmed, Nan van Geloven, Rob J de Haan, Paul J Nederkoorn
发表日期
2011/9
来源
Stroke
卷号
42
期号
9
页码范围
2515-2520
出版商
Lippincott Williams & Wilkins
简介
Background and Purpose
The safety and efficacy of thrombolysis in cervical artery dissection (CAD) are controversial. The aim of this meta-analysis was to pool all individual patient data and provide a valid estimate of safety and outcome of thrombolysis in CAD.
Methods
We performed a systematic literature search on intravenous and intra-arterial thrombolysis in CAD. We calculated the rates of pooled symptomatic intracranial hemorrhage and mortality and indirectly compared them with matched controls from the Safe Implementation of Thrombolysis in Stroke–International Stroke Thrombolysis Register. We applied multivariate regression models to identify predictors of excellent (modified Rankin Scale=0 to 1) and favorable (modified Rankin Scale=0 to 2) outcome.
Results
We obtained individual patient data of 180 patients from 14 retrospective series and 22 case reports. Patients were predominantly female (68 …
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SM Zinkstok, MDI Vergouwen, ST Engelter, PA Lyrer… - Stroke, 2011