作者
Siddhartha Laskar, Shwetabh Sinha, Abhishek Chatterjee, Nehal Khanna, Jifmi Jose Manjali, Ajay Puri, Ashish Gulia, Prakash Nayak, Tushar Vora, Girish Chinnaswamy, Maya Prasad, Jyoti Bajpai, Shashikant Juvekar, Subhash Desai, Amit Janu, Venkatesh Rangarajan, Nilendu Purandare, Sneha Shah, Bharat Rekhi, Nirmala Jambhekar, Mary Ann Muckaden, Purna Kurkure
发表日期
2022/8/1
期刊
International Journal of Radiation Oncology* Biology* Physics
卷号
113
期号
5
页码范围
996-1002
出版商
Elsevier
简介
Purpose
Our aim was to assess the effect of radiation therapy (RT) dose escalation on outcomes in surgically unresectable Ewing sarcoma (ES)/primitive neuroectodermal tumor (PNET).
Methods and Materials
Patients with nonmetastatic unresectable ES/PNET (excluding intracranial/chest wall) receiving vincristine, doxorubicin, cyclophosphamide, ifosfamide, and etoposide chemotherapy, planned for definitive RT, were accrued in this single-institution, open-label, phase 3 randomized controlled trial. Randomization was between standard dose RT (SDRT; 55.8 Gy/31 fractions/5 days a week) versus escalated dose RT (EDRT; 70.2 Gy/39 fractions/5 days a week) with a primary objective of improving local control (LC) by 17% (65%-82%). Secondary outcomes included disease-free survival (DFS), overall survival (OS), and functional outcomes by Musculoskeletal Tumor Society score.
Results
Between April 2005 and …
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S Laskar, S Sinha, A Chatterjee, N Khanna, JJ Manjali… - International Journal of Radiation Oncology* Biology …, 2022