作者
Barbara V Howard, Linda Van Horn, Judith Hsia, JoAnn E Manson, Marcia L Stefanick, Sylvia Wassertheil-Smoller, Lewis H Kuller, Andrea Z LaCroix, Robert D Langer, Norman L Lasser, Cora E Lewis, Marian C Limacher, Karen L Margolis, W Jerry Mysiw, Judith K Ockene, Linda M Parker, Michael G Perri, Lawrence Phillips, Ross L Prentice, John Robbins, Jacques E Rossouw, Gloria E Sarto, Irwin J Schatz, Linda G Snetselaar, Victor J Stevens, Lesley F Tinker, Maurizio Trevisan, Mara Z Vitolins, Garnet L Anderson, Annlouise R Assaf, Tamsen Bassford, Shirley AA Beresford, Henry R Black, Robert L Brunner, Robert G Brzyski, Bette Caan, Rowan T Chlebowski, Margery Gass, Iris Granek, Philip Greenland, Jennifer Hays, David Heber, Gerardo Heiss, Susan L Hendrix, F Allan Hubbell, Karen C Johnson, Jane Morley Kotchen
发表日期
2006/2/8
期刊
Jama
卷号
295
期号
6
页码范围
655-666
出版商
American Medical Association
简介
ContextMultiple epidemiologic studies and some trials have linked diet with cardiovascular disease (CVD) prevention, but long-term intervention data are needed.ObjectiveTo test the hypothesis that a dietary intervention, intended to be low in fat and high in vegetables, fruits, and grains to reduce cancer, would reduce CVD risk.Design, Setting, and ParticipantsRandomized controlled trial of 48 835 postmenopausal women aged 50 to 79 years, of diverse backgrounds and ethnicities, who participated in the Women's Health Initiative Dietary Modification Trial. Women were randomly assigned to an intervention (19 541 [40%]) or comparison group (29 294 [60%]) in a free-living setting. Study enrollment occurred between 1993 and 1998 in 40 US clinical centers; mean follow-up in this analysis was 8.1 years.InterventionIntensive behavior modification in group and individual sessions designed to reduce total fat intake …
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BV Howard, L Van Horn, J Hsia, JAE Manson… - Jama, 2006