作者
JoAnn E Manson, Matthew A Allison, Jacques E Rossouw, J Jeffrey Carr, Robert D Langer, Judith Hsia, Lewis H Kuller, Barbara B Cochrane, Julie R Hunt, Shari E Ludlam, Mary B Pettinger, Margery Gass, Karen L Margolis, Lauren Nathan, Judith K Ockene, Ross L Prentice, John Robbins, Marcia L Stefanick
发表日期
2007/6/21
期刊
New England Journal of Medicine
卷号
356
期号
25
页码范围
2591-2602
出版商
Massachusetts Medical Society
简介
Background
Calcified plaque in the coronary arteries is a marker for atheromatous-plaque burden and is predictive of future risk of cardiovascular events. We examined the relationship between estrogen therapy and coronary-artery calcium in the context of a randomized clinical trial.
Methods
In our ancillary substudy of the Women's Health Initiative trial of conjugated equine estrogens (0.625 mg per day) as compared with placebo in women who had undergone hysterectomy, we performed computed tomography of the heart in 1064 women aged 50 to 59 years at randomization. Imaging was conducted at 28 of 40 centers after a mean of 7.4 years of treatment and 1.3 years after the trial was completed (8.7 years after randomization). Coronary-artery calcium (or Agatston) scores were measured at a central reading center without knowledge of randomization status.
Results
The mean coronary-artery calcium score …
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JAE Manson, MA Allison, JE Rossouw, JJ Carr… - New England Journal of Medicine, 2007