作者
Ross L Prentice, Bette Caan, Rowan T Chlebowski, Ruth Patterson, Lewis H Kuller, Judith K Ockene, Karen L Margolis, Marian C Limacher, JoAnn E Manson, Linda M Parker, Electra Paskett, Lawrence Phillips, John Robbins, Jacques E Rossouw, Gloria E Sarto, James M Shikany, Marcia L Stefanick, Cynthia A Thomson, Linda Van Horn, Mara Z Vitolins, Jean Wactawski-Wende, Robert B Wallace, Sylvia Wassertheil-Smoller, Evelyn Whitlock, Katsuhiko Yano, Lucile Adams-Campbell, Garnet L Anderson, Annlouise R Assaf, Shirley AA Beresford, Henry R Black, Robert L Brunner, Robert G Brzyski, Leslie Ford, Margery Gass, Jennifer Hays, David Heber, Gerardo Heiss, Susan L Hendrix, Judith Hsia, F Allan Hubbell, Rebecca D Jackson, Karen C Johnson, Jane Morley Kotchen, Andrea Z LaCroix, Dorothy S Lane, Robert D Langer, Norman L Lasser, Maureen M Henderson
发表日期
2006/2/8
期刊
Jama
卷号
295
期号
6
页码范围
629-642
出版商
American Medical Association
简介
ContextThe hypothesis that a low-fat dietary pattern can reduce breast cancer risk has existed for decades but has never been tested in a controlled intervention trial.ObjectiveTo assess the effects of undertaking a low-fat dietary pattern on breast cancer incidence.Design and SettingA randomized, controlled, primary prevention trial conducted at 40 US clinical centers from 1993 to 2005.ParticipantsA total of 48 835 postmenopausal women, aged 50 to 79 years, without prior breast cancer, including 18.6% of minority race/ethnicity, were enrolled.InterventionsWomen were randomly assigned to the dietary modification intervention group (40% [n = 19 541]) or the comparison group (60% [n = 29 294]). The intervention was designed to promote dietary change with the goals of reducing intake of total fat to 20% of energy and increasing consumption of vegetables and fruit to at least 5 servings daily and grains to at least 6 …
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RL Prentice, B Caan, RT Chlebowski, R Patterson… - Jama, 2006