作者
Shirley AA Beresford, Karen C Johnson, Cheryl Ritenbaugh, Norman L Lasser, Linda G Snetselaar, Henry R Black, Garnet L Anderson, Annlouise R Assaf, Tamsen Bassford, Deborah Bowen, Robert L Brunner, Robert G Brzyski, Bette Caan, Rowan T Chlebowski, Margery Gass, Rosanne C Harrigan, Jennifer Hays, David Heber, Gerardo Heiss, Susan L Hendrix, Barbara V Howard, Judith Hsia, F Allan Hubbell, Rebecca D Jackson, Jane Morley Kotchen, Lewis H Kuller, Andrea Z LaCroix, Dorothy S Lane, Robert D Langer, Cora E Lewis, JoAnn E Manson, Karen L Margolis, Yasmin Mossavar-Rahmani, Judith K Ockene, Linda M Parker, Michael G Perri, Lawrence Phillips, Ross L Prentice, John Robbins, Jacques E Rossouw, Gloria E Sarto, Marcia L Stefanick, Linda Van Horn, Mara Z Vitolins, Jean Wactawski-Wende, Robert B Wallace, Evelyn Whitlock
发表日期
2006/2/8
期刊
Jama
卷号
295
期号
6
页码范围
643-654
出版商
American Medical Association
简介
ContextObservational studies and polyp recurrence trials are not conclusive regarding the effects of a low-fat dietary pattern on risk of colorectal cancer, necessitating a primary prevention trial.ObjectiveTo evaluate the effects of a low-fat eating pattern on risk of colorectal cancer in postmenopausal women.Design, Setting, and ParticipantsThe Women’s Health Initiative Dietary Modification Trial, a randomized controlled trial conducted in 48 835 postmenopausal women aged 50 to 79 years recruited between 1993 and 1998 from 40 clinical centers throughout the United States.InterventionsParticipants were randomly assigned to the dietary modification intervention (n = 19 541; 40%) or the comparison group (n = 29 294; 60%).The intensive behavioral modification program aimed to motivate and support reductions in dietary fat, to increase consumption of vegetables and fruits, and to increase grain servings by using …
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SAA Beresford, KC Johnson, C Ritenbaugh, NL Lasser… - Jama, 2006