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Interstitial lung abnormalities (ILA) often represent early fibrotic changes that can portend a progressive fibrotic phenotype. In particular, the fibrotic subtype of ILA is associated with increased mortality and rapid decline in lung function. Understanding the differential gene expression in the lungs of participants with fibrotic ILA may provide insight into development of a useful biomarker for early detection and therapeutic targets for progressive pulmonary fibrosis. Measures of ILA were available for 451 participants and gene expression data was available for 350 participants in the Detection of Early Lung Cancer Among Military Personnel (DECAMP) cohort. ILA was defined using Fleischner Society guidelines and determined by sequential reading of computed tomography (CT) scans. Fibrotic ILA was defined by the presence of traction bronchiectasis or honeycombing associated with ILA. RNA was …