作者
C Lloyd, A Dessein, PM Preux, M Dumas, C Larralde, E Sciutto, G Fragoso, S Fredrikson, Q Cheng, G-X Jiang, D Wasserman, M Huerta, A Chavarria, RA Carrillo Mezo, Peter D Inskip, Robert E Tarone, Elizabeth E Hatch, Robert G Hart, Raymond A Faber, Timothy C Wilcosky, Robert G Selker, Howard A Fine, Peter McL Black, Jay S Loeffler, William R Shapiro, Douglas A Dulli, Heather Stanko, Ross L Levine, Lennart Hardell, Kjell Hansson Mild, Monica Sandström, Michael Carlberg, Arne Hallquist, Anneli Påhlson, Martha S Linet, A Fleury, T Gomez, I Alvarez, D Meza, Cristina Cusi, Livia Candelise
发表日期
2003
来源
Neuroepidemiology
卷号
22
期号
2
页码范围
106-117
出版商
Karger Publishers
简介
Background and Relevance: Atherosclerotic stenosis of the major intracranial arteries is an important cause of transient ischemic attack (TIA) or stroke. Of the 900,000 patients who suffer a TIA or stroke each year in the USA, intracranial stenosis is responsible for approximately 10%, i.e. 90,000 patients. There have been no prospective trials evaluating antithrombotic therapies for preventing recurrent vascular events in these patients. The main objective of this trial is to compare warfarin [International Normalized Ratio (INR) 2–3] with aspirin (1,300 mg/day) for preventing stroke (ischemic and hemorrhagic) and vascular death in patients presenting with TIA or stroke caused by stenosis of a major intracranial artery. Study Design: Prospective, randomized, double-blind, multicenter trial. The sample sizerequired will be 403 patients per group, based on stroke and vascular death rates of 33% per 3 years in the aspirin …
引用总数
学术搜索中的文章
C Lloyd, A Dessein, PM Preux, M Dumas, C Larralde… - Neuroepidemiology, 2003