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Prior research yielded conflicting results about the magnitude of the association between body mass index (BMI) and chronic kidney disease (CKD).

Prospective cohort study.

Framingham Offspring participants (n = 2,676; 52% women; mean age, 43 years) free of stage 3 CKD at baseline who participated in examination cycles 2 (1978-1981) and 7 (1998-2001).

BMI.

Stage 3 CKD (estimated glomerular filtration rate < 59 mL/min/1.73 m² [<0.98 mL/s/1.73 m²] for women and < 64 mL/min/1.73 m² [<1.07 mL/s/1.73 m²] for men).

Age-, sex-, and multivariable-adjusted (diabetes, systolic blood pressure, hypertension treatment, current smoking status, and high-density lipoprotein cholesterol level) logistic regression models were used to examine the relationship between BMI at baseline and incident stage 3 CKD …