作者
Mauricio P Pinto, Matías Muñoz Medel, Diego Carrillo, Ignacio N Retamal, M Loreto Bravo, Yasna Valenzuela, Bruno Nervi, César Sánchez, Héctor Galindo, Carolina Ibañez, José Peña, Carlos Balmaceda, Jorge Madrid, Juan Briones, Javiera Torres, Flavia Nilo, Francisco J Guarda, Juan Carlos Quintana, Pilar Orellana, Sebastián Mondaca, Francisco Acevedo, Daniel Vicentini, Miguel Cordova-Delgado, Gareth I Owen, Marcelo Garrido
发表日期
2019/2
期刊
Hormones and Cancer
卷号
10
页码范围
3-10
出版商
Springer US
简介
Neuroendocrine tumors (NETs) are relatively rare and highly heterogeneous neoplasms. Despite this, recent studies from North America and Central Europe have suggested an increase in incidence. In Latin America, NET data are scarce and scattered with only a few studies reporting registries. Our goal was to establish a NET registry in Chile. Here, we report the establishment and our first 166 NET patients. We observed a slight preponderance of males, a median age at diagnosis of 53 years and a median overall survival of 110 months. As anticipated, most tumors were gastroenteropancreatic (GEP). Survival analyses demonstrated that non-GEP or stage IV tumors presented significantly lower overall survival (OS). Similarly, patients with surgery classified as R0 had better OS compared to R1, R2, or no surgery. Furthermore, patients with elevated chromogranin A (CgA) or high Ki67 showed a trend to …
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MP Pinto, M Muñoz Medel, D Carrillo, IN Retamal… - Hormones and Cancer, 2019