作者
Giulio Disanto, Christian Barro, Pascal Benkert, Yvonne Naegelin, Sabine Schädelin, Antonella Giardiello, Chiara Zecca, Kaj Blennow, Henrik Zetterberg, David Leppert, Ludwig Kappos, Claudio Gobbi, Jens Kuhle, Swiss Multiple Sclerosis Cohort Study Group, Jens Kuhle, Johannes Lorscheider, Özgür Yaldizli, Tobias Derfuss, Ludwig Kappos, Giulio Disanto, Chiara Zecca, Claudio Gobbi, Pascal Benkert, Lutz Achtnichts, Krassen Nedeltchev, Christian P Kamm, Anke Salmen, Andrew Chan, Patrice H Lalive, Caroline Pot, Myriam Schluep, Cristina Granziera, Renaud Du Pasquier, Stefanie Müller, Jochen Vehoff
发表日期
2017/6
期刊
Annals of neurology
卷号
81
期号
6
页码范围
857-870
简介
Objective
Neurofilament light chains (NfL) are unique to neuronal cells, are shed to the cerebrospinal fluid (CSF), and are detectable at low concentrations in peripheral blood. Various diseases causing neuronal damage have resulted in elevated CSF concentrations. We explored the value of an ultrasensitive single‐molecule array (Simoa) serum NfL (sNfL) assay in multiple sclerosis (MS).
Methods
sNfL levels were measured in healthy controls (HC, n = 254) and two independent MS cohorts: (1) cross‐sectional with paired serum and CSF samples (n = 142), and (2) longitudinal with repeated serum sampling (n = 246, median follow‐up = 3.1 years, interquartile range [IQR] = 2.0–4.0). We assessed their relation to concurrent clinical, imaging, and treatment parameters and to future clinical outcomes.
Results
sNfL levels were higher in both MS cohorts than in HC (p < 0.001). We found a strong association between …
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G Disanto, C Barro, P Benkert, Y Naegelin, S Schädelin… - Annals of neurology, 2017