作者
Alessandro Cagol, Sabine Schaedelin, Muhamed Barakovic, Pascal Benkert, Ramona-Alexandra Todea, Reza Rahmanzadeh, Riccardo Galbusera, Po-Jui Lu, Matthias Weigel, Lester Melie-Garcia, Esther Ruberte, Nina Siebenborn, Marco Battaglini, Ernst-Wilhelm Radue, Özgür Yaldizli, Johanna Oechtering, Tim Sinnecker, Johannes Lorscheider, Bettina Fischer-Barnicol, Stefanie Müller, Lutz Achtnichts, Jochen Vehoff, Giulio Disanto, Oliver Findling, Andrew Chan, Anke Salmen, Caroline Pot, Claire Bridel, Chiara Zecca, Tobias Derfuss, Johanna M Lieb, Luca Remonda, Franca Wagner, Maria I Vargas, Renaud Du Pasquier, Patrice H Lalive, Emanuele Pravatà, Johannes Weber, Philippe C Cattin, Claudio Gobbi, David Leppert, Ludwig Kappos, Jens Kuhle, Cristina Granziera
发表日期
2022/7/1
期刊
JAMA neurology
卷号
79
期号
7
页码范围
682-692
出版商
American Medical Association
简介
Importance
The mechanisms driving neurodegeneration and brain atrophy in relapsing multiple sclerosis (RMS) are not completely understood.
Objective
To determine whether disability progression independent of relapse activity (PIRA) in patients with RMS is associated with accelerated brain tissue loss.
Design, Setting, and Participants
In this observational, longitudinal cohort study with median (IQR) follow-up of 3.2 years (2.0-4.9), data were acquired from January 2012 to September 2019 in a consortium of tertiary university and nonuniversity referral hospitals. Patients were included if they had regular clinical follow-up and at least 2 brain magnetic resonance imaging (MRI) scans suitable for volumetric analysis. Data were analyzed between January 2020 and March 2021.
Exposures
According to the clinical evolution during the entire observation, patients were classified as those presenting (1) relapse activity …
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A Cagol, S Schaedelin, M Barakovic, P Benkert… - JAMA neurology, 2022