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The electrochemical oxidation of Ezogabine (EZG) based on Graphene Oxide Nanosheets (GO) and Ionic Liquids (IL)-modified carbon paste electrodes (CPE) has been studied using different techniques. GO and IL have a synergetic effect giving rise to highly improved electrochemical responses and provide an advantageous platform for the basis of an electrochemical sensor with excellent performance. Screening for the best experimental conditions was performed by fractional factorial design, while optimization studies were performed with the aid of central composite design. The optimum conditions were located by the use of Derringer's desirability function. The sensing of EZG via square wave voltammetry (SWV) is found to exhibit two wide linear dynamic ranges of 9.89 × 10⁻⁷–1.92 × 10⁻⁵ M and 1.92 × 10⁻⁵–2.0 × 10⁻⁴ M at pH 2.0. The limits of detection and quantification were calculated to be 9 …