作者
Mark Lebwohl, Bruce Strober, Alan Menter, Kenneth Gordon, Jolanta Weglowska, Lluis Puig, Kim Papp, Lynda Spelman, Darryl Toth, Francisco Kerdel, April W Armstrong, Georg Stingl, Alexa B Kimball, Herve Bachelez, Jashin J Wu, Jeffrey Crowley, Richard G Langley, Tomasz Blicharski, Carle Paul, Jean-Philippe Lacour, Stephen Tyring, Leon Kircik, Sergio Chimenti, Kristina Callis Duffin, Jerry Bagel, John Koo, Gary Aras, Joanne Li, Wenjie Song, Cassandra E Milmont, Yifei Shi, Ngozi Erondu, Paul Klekotka, Brian Kotzin, Ajay Nirula
发表日期
2015/10/1
期刊
New England Journal of Medicine
卷号
373
期号
14
页码范围
1318-1328
出版商
Massachusetts Medical Society
简介
Background
Early clinical studies suggested that the anti–interleukin-17 receptor A monoclonal antibody brodalumab has efficacy in the treatment of psoriasis.
Methods
In two phase 3 studies (AMAGINE-2 and AMAGINE-3), patients with moderate-to-severe psoriasis were randomly assigned to receive brodalumab (210 mg or 140 mg every 2 weeks), ustekinumab (45 mg for patients with a body weight ≤100 kg and 90 mg for patients >100 kg), or placebo. At week 12, patients receiving brodalumab were randomly assigned again to receive a brodalumab maintenance dose of 210 mg every 2 weeks or 140 mg every 2 weeks, every 4 weeks, or every 8 weeks; patients receiving ustekinumab continued to receive ustekinumab every 12 weeks, and patients receiving placebo received 210 mg of brodalumab every 2 weeks. The primary aims were to evaluate the superiority of brodalumab over placebo at week 12 with …
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M Lebwohl, B Strober, A Menter, K Gordon… - New England Journal of Medicine, 2015