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Quantification of left ventricular ejection fraction (LVEF) by transthoracic echocardiography (TTE) is operator‐dependent, time‐consuming, and error‐prone. LVivoEF by DIA is a new artificial intelligence (AI) software, which displays the tracking of endocardial borders and rapidly quantifies LVEF. We sought to assess the accuracy of LVivoEF compared to cardiac magnetic resonance imaging (cMRI) as the reference standard and to compare LVivoEF to the standard‐of‐care physician‐measured LVEF (MD‐EF) including studies with ultrasound enhancing agents (UEAs).

In 273 consecutive patients, we compared MD‐EF and AI‐derived LVEF to cMRI. AI‐derived LVEF was obtained from a non‐UEA four‐chamber view without manual correction. Thirty‐one patients were excluded: 25 had interval interventions or incomplete TTE or cMRI studies and six had uninterpretable non‐UEA apical …