作者
Kazuya Sumi, Haruhiro Inoue, Yasutoshi Kobayashi, Yugo Iwaya, Mary Raina Angeli Abad, Yusuke Fujiyoshi, Yuto Shimamura, Haruo Ikeda, Manabu Onimaru
发表日期
2021/3
期刊
Digestive Endoscopy
卷号
33
期号
3
页码范围
347-354
简介
Objectives
Some patients with gastroesophageal reflux disease (GERD) are refractory to proton pump inhibitor (PPI) therapy. Anti‐reflux mucosectomy (ARMS) is a minimally invasive endoscopic procedure for treatment of GERD. In this study, we retrospectively evaluated the outcomes of ARMS performed in patients with PPI‐refractory GERD at our institution.
Methods
A total of 109 patients with PPI‐refractory GERD who underwent ARMS were retrospectively reviewed. Pre‐ and post‐ARMS questionnaire scores, acid exposure time (AET), DeMeester score, proximal extent, and PPI discontinuation rate were compared.
Results
There was a significant improvement in the symptom score (P < 0.01) and 40–50% of patients were able to discontinue PPI after ARMS. In patients who were followed up for 3 years, sustained improvement in subjective symptoms was observed. AET and DeMeester score significantly …
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K Sumi, H Inoue, Y Kobayashi, Y Iwaya, MRA Abad… - Digestive Endoscopy, 2021