作者
Nelson E Arenas, Luz M Salazar, Carlos Y Soto, Carolina Vizcaíno, Manuel E Patarroyo, Manuel A Patarroyo, Arley Gómez
发表日期
2011/12
期刊
BMC Structural Biology
卷号
11
页码范围
1-11
出版商
BioMed Central
简介
Background
The TlyA protein has a controversial function as a virulence factor in Mycobacterium tuberculosis (M. tuberculosis). At present, its dual activity as hemolysin and RNA methyltransferase in M. tuberculosis has been indirectly proposed based on in vitro results. There is no evidence however for TlyA relevance in the survival of tubercle bacilli inside host cells or whether both activities are functionally linked. A thorough analysis of structure prediction for this mycobacterial protein in this study shows the need for reevaluating TlyA's function in virulence.
Results
Bioinformatics analysis of TlyA identified a ribosomal protein binding domain (S4 domain), located between residues 5 and 68 as well as an FtsJ-like methyltranferase domain encompassing residues 62 and 247, all of which have been previously described in translation machinery-associated …
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NE Arenas, LM Salazar, CY Soto, C Vizcaíno… - BMC Structural Biology, 2011