作者
Yuanli Chen, Yajun Duan, Xiaoxiao Yang, Lei Sun, Mengyang Liu, Qixue Wang, Xingzhe Ma, Wenwen Zhang, Xiaoju Li, Wenquan Hu, Robert Q Miao, Rong Xiang, David P Hajjar, Jihong Han
发表日期
2015/4
期刊
Arteriosclerosis, thrombosis, and vascular biology
卷号
35
期号
4
页码范围
948-959
出版商
Lippincott Williams & Wilkins
简介
Objective
Activation of liver X receptor (LXR) inhibits atherosclerosis but induces hypertriglyceridemia. In vitro, it has been shown that mitogen-activated protein kinase kinase 1/2 (MEK1/2) inhibitor synergizes LXR ligand–induced macrophage ABCA1 expression and cholesterol efflux. In this study, we determined whether MEK1/2 (U0126) and LXR ligand (T0901317) can have a synergistic effect on the reduction of atherosclerosis while eliminating LXR ligand–induced fatty livers and hypertriglyceridemia. We also set out to identify the cellular mechanisms of the actions.
Approach and Results
Wild-type mice were used to determine the effect of U0126 on a high-fat diet or high-fat diet plus T0901317-induced transient dyslipidemia and liver injury. ApoE deficient (apoE−/−) mice or mice with advanced lesions were used to determine the effect of the combination of T0901317 and U0126 on atherosclerosis and …
学术搜索中的文章
Y Chen, Y Duan, X Yang, L Sun, M Liu, Q Wang, X Ma… - Arteriosclerosis, thrombosis, and vascular biology, 2015