作者
S Evelyn Stewart, Dongmei Yu, Jeremiah M Scharf, Benjamin M Neale, Jesen A Fagerness, Carol A Mathews, Paul D Arnold, Patrick D Evans, Eric R Gamazon, Lisa Osiecki, Lauren McGrath, Stephen Haddad, Jacquelyn Crane, Dianne Hezel, Cornelia Illman, Catherine Mayerfeld, Anuar Konkashbaev, Chunyu Liu, Anna Pluzhnikov, Anna Tikhomirov, Christopher K Edlund, Scott L Rauch, Rainald Moessner, Peter Falkai, Wolfgang Maier, Stephan Ruhrmann, Hans-Jörgen Grabe, Leonard Lennertz, Michael Wagner, Laura Bellodi, Maria Cristina Cavallini, Margaret A Richter, EH Cook, James L Kennedy, David Rosenberg, Dan J Stein, Sian MJ Hemmings, Christine Lochner, Amin Azzam, Denise A Chavira, Eduardo Fournier, Helena Garrido, Brooke Sheppard, Paul Umaña, Dennis L Murphy, Jens R Wendland, Jeremy Veenstra-VanderWeele, Damiaan Denys, Rianne Blom, Dieter Deforce, Filip Van Nieuwerburgh, Herman GM Westenberg, Susanne Walitza, Karin Egberts, Tobias Renner, Euripedes Constantino Miguel, Carolina Cappi, Ana G Hounie, M Conceição do Rosário, Aline S Sampaio, Homero Vallada, Humberto Nicolini, Nuria Lanzagorta, Beatriz Camarena, Richard Delorme, Marion Leboyer, Carlos N Pato, Michele T Pato, Emanuel Voyiaziakis, Peter Heutink, Danielle C Cath, Danielle Posthuma, Jan H Smit, Jack Samuels, O Joseph Bienvenu, Bernadette Cullen, Abby J Fyer, Marco A Grados, Benjamin D Greenberg, James T McCracken, Mark A Riddle, Youfa Wang, Vladimir Coric, James F Leckman, Michael Bloch, Christopher Pittenger, Valsamma Eapen, Donald W Black, Roel A Ophoff, Eric Strengman, Daniele Cusi, Maurizio Turiel, Francesca Frau, Fabio Macciardi, J Raphael Gibbs, Mark R Cookson, Andrew Singleton, John Hardy, Andrew T Crenshaw, Melissa A Parkin, Daniel B Mirel, David V Conti, Shaun Purcell, Gerald Nestadt, Gregory L Hanna, Michael A Jenike, James A Knowles, Nancy Cox, David L Pauls
发表日期
2013/7
期刊
Molecular psychiatry
卷号
18
期号
7
页码范围
788-798
出版商
Nature Publishing Group
简介
Obsessive-compulsive disorder (OCD) is a common, debilitating neuropsychiatric illness with complex genetic etiology. The International OCD Foundation Genetics Collaborative (IOCDF-GC) is a multi-national collaboration established to discover the genetic variation predisposing to OCD. A set of individuals affected with DSM-IV OCD, a subset of their parents, and unselected controls, were genotyped with several different Illumina SNP microarrays. After extensive data cleaning, 1465 cases, 5557 ancestry-matched controls and 400 complete trios remained, with a common set of 469 410 autosomal and 9657 X-chromosome single nucleotide polymorphisms (SNPs). Ancestry-stratified case–control association analyses were conducted for three genetically-defined subpopulations and combined in two meta-analyses, with and without the trio-based analysis. In the case–control analysis, the lowest two P-values …
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SE Stewart, D Yu, JM Scharf, BM Neale, JA Fagerness… - Molecular psychiatry, 2013