作者
Stella J De Wit, Pino Alonso, Lizanne Schweren, David Mataix-Cols, Christine Lochner, José M Menchón, Dan J Stein, Jean-Paul Fouche, Carles Soriano-Mas, Joao R Sato, Marcelo Q Hoexter, Damiaan Denys, Takashi Nakamae, Seiji Nishida, Jun Soo Kwon, Joon Hwan Jang, Geraldo F Busatto, Narcís Cardoner, Danielle C Cath, Kenji Fukui, Wi Hoon Jung, Sung Nyun Kim, Euripides C Miguel, Jin Narumoto, Mary L Phillips, Jesus Pujol, Peter L Remijnse, Yuki Sakai, Na Young Shin, Kei Yamada, Dick J Veltman, Odile A Van Den Heuvel
发表日期
2014/3
期刊
American journal of psychiatry
卷号
171
期号
3
页码范围
340-349
出版商
American Psychiatric Association
简介
Objective
Results from structural neuroimaging studies of obsessive-compulsive disorder (OCD) have been only partially consistent. The authors sought to assess regional gray and white matter volume differences between large samples of OCD patients and healthy comparison subjects and their relation with demographic and clinical variables.
Method
A multicenter voxel-based morphometry mega-analysis was performed on 1.5-T structural T1-weighted MRI scans derived from the International OCD Brain Imaging Consortium. Regional gray and white matter brain volumes were compared between 412 adult OCD patients and 368 healthy subjects.
Results
Relative to healthy comparison subjects, OCD patients had significantly smaller volumes of frontal gray and white matter bilaterally, including the dorsomedial prefrontal cortex, the anterior cingulate cortex, and the inferior frontal gyrus extending to the anterior …
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SJ De Wit, P Alonso, L Schweren, D Mataix-Cols… - American journal of psychiatry, 2014
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