作者
Subash C Gupta, Anurag Sharma, Manish Mishra, Ranjit K Mishra, Debapratim K Chowdhuri
发表日期
2010/3/13
来源
Life sciences
卷号
86
期号
11-12
页码范围
377-384
出版商
Pergamon
简介
The response to stress triggers activation of the genes involved in cell survival and/or cell death. Stress response is a ubiquitous feature of cells that is induced under stress conditions. As a part of this response a set of genes called stress genes are induced to synthesize a group of proteins called heat shock proteins (Hsps). The Hsps play an essential role as molecular chaperones by assisting the correct folding of nascent and stress-accumulated misfolded proteins, and by preventing their aggregation. Because of their sensitivity to even minor assaults, Hsps are suitable as an early warning bio-indicator of cellular hazard. Despite having enormous use in toxicology, the current state of knowledge in defining a mechanism of action or accurately predicting toxicity based on stress gene expression warrants further investigation. The goal of this review is to summarize current developments in the application of stress …
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SC Gupta, A Sharma, M Mishra, RK Mishra… - Life sciences, 2010