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The aim of this study is to estimate the age-dependent force of infection for hepatitis B virus (HBV) for sick patients showing symptoms, blood donors and people coming to the serology department to test for the antigen in blood voluntarily. A secondary data was obtained from the serology department at the Komfo Anokye Teaching Hospital (KATH, January 2013-June 2016). Linear and quadratic agedependent beta regression models were fitted to the prevalence of HBV. From the results, the estimated quadratic model was suitable for the mean prevalence of HBV, with a significant positive linear and negative quadratic age effects respectively. From the results, the prevalence increases from lower ages to age 38 and decreases at higher ages. The estimated force of infection for the heterogeneous group is high at lower ages, decreases to age 38 and increases to age 64. In conclusion, the prevalence is high at age 38 and the transmission rate is lower at age 38 but higher at age 11 and 64.