作者
Shima Mohammadi, Latifeh Karimzadeh Bardei, Vida Hojati, Azita Ghorbani, Mohammad Nabiuni
发表日期
2017
期刊
Cell Journal (Yakhteh)
卷号
19
期号
3
页码范围
425
出版商
Royan Institute
简介
Objective
Curcumin protects the liver against injury and fibrosis through suppressing hepatic inflammation, attenuating hepatic oxidative stress (OS), and inhibiting hepatic stellate cells (HSCs) activation. Non-alcoholic fatty liver disease (NAFLD) and polycystic ovary syndrome (PCOS) are considered as common metabolic disorders. Low-grade chronic inflammation with different markers, such as elevated C-reactive protein (CRP) and interleukin-6 (IL-6) levels, play a crucial role in PCOS. This study aimed to evaluate the therapeutic effects of curcumin on IL-6 and CRP levels as well as insulin resistance (IR) index on liver function in PCOS rats.
Materials and Methods
In this experimental study, 90 adult Wistar rats were divided into control (n= 18), sham (n= 18), PCOS (n= 18) and curcumin-treated PCOS groups (n= 36). PCOS group was injected subcutaneously with 2 mg estradio-valerate (E2V). After 60 days, PCOS …
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S Mohammadi, LK Bardei, V Hojati, A Ghorbani… - Cell Journal (Yakhteh), 2017