查看文章

Objective

Curcumin protects the liver against injury and fibrosis through suppressing hepatic inflammation, attenuating hepatic oxidative stress (OS), and inhibiting hepatic stellate cells (HSCs) activation. Non-alcoholic fatty liver disease (NAFLD) and polycystic ovary syndrome (PCOS) are considered as common metabolic disorders. Low-grade chronic inflammation with different markers, such as elevated C-reactive protein (CRP) and interleukin-6 (IL-6) levels, play a crucial role in PCOS. This study aimed to evaluate the therapeutic effects of curcumin on IL-6 and CRP levels as well as insulin resistance (IR) index on liver function in PCOS rats.

Materials and Methods

In this experimental study, 90 adult Wistar rats were divided into control (n= 18), sham (n= 18), PCOS (n= 18) and curcumin-treated PCOS groups (n= 36). PCOS group was injected subcutaneously with 2 mg estradio-valerate (E2V). After 60 days, PCOS …