作者
Lisa Martin, Laura Birdsell, Neil MacDonald, Tony Reiman, M Thomas Clandinin, Linda J McCargar, Rachel Murphy, Sunita Ghosh, Michael B Sawyer, Vickie E Baracos
发表日期
2013/4/20
期刊
Journal of clinical oncology
卷号
31
期号
12
页码范围
1539-1547
出版商
American Society of Clinical Oncology
简介
Purpose
Emerging evidence suggests muscle depletion predicts survival of patients with cancer.
Patients and Methods
At a cancer center in Alberta, Canada, consecutive patients with cancer (lung or GI; N = 1,473) were assessed at presentation for weight loss history, lumbar skeletal muscle index, and mean muscle attenuation (Hounsfield units) by computed tomography (CT). Univariate and multivariate analyses were conducted. Concordance (c) statistics were used to test predictive accuracy of survival models.
Results
Body mass index (BMI) distribution was 17% obese, 35% overweight, 36% normal weight, and 12% underweight. Patients in all BMI categories varied widely in weight loss, muscle index, and muscle attenuation. Thresholds defining associations between these three variables and survival were determined using optimal stratification. High weight loss, low muscle index, and low muscle …
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L Martin, L Birdsell, N MacDonald, T Reiman… - Journal of clinical oncology, 2013