作者
Fania El Ridhasya, Novia Rahim, Muhammad Almurdani, Rudi Hendra, Hilwan Yuda Teruna
发表日期
2020
期刊
Pharmacognosy Journal
卷号
12
期号
2
简介
Background
The roots of tunjuk langit (Helminthostacshys zeylanica) have been used traditionally in some villages in Indonesia, particularly in Riau Province.
Objective
In this study we reported two flavonoids and their antidiabetic activity.
Material and methods
Isolation of the metabolites was based on polarity fractionation method. Purification processes were conducted by vacuum liquid chromatography (VLC). Chemical structures were elucidated based on spectroscopy characteristics, including FTIR and 1D/2D NMR.
Results
The isolated compounds were identified as ugonin J and K. The antidiabetic activity was measured by α-glucosidase inhibitor assay. The antidiabetic activity of ugonin J was found at IC 50 273, 13±0,402 ppm and Ugonin K was found at IC 50 138, 21±0,263 ppm (moderately active).
Conclusion
Therefore this plant can be used traditionally as antidiabetic medicine.
引用总数
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