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Purpose:

To observe how variations in intraocular pressure (IOP) correlate with the flow of aqueous in episcleral veins.

Design:

Prospective observational cohort study.

Participants:

The WDT increased AO into the episcleral venous system in 30 eyes recruited from Sydney Eye Hospital. A comparison was made between glaucomatous (n= 20) and nonglaucomatous eyes (n= 10).

Methods:

Each patient had baseline IOP and HVI before drinking 10 mL/kg body weight of water. IOP and HVI were then repeated every 15 minutes for 1 hour. Aqueous column cross-sectional area (AqCA) of the most prominent nasal and temporal aqueous veins was used to semi-quantify conventional AO.

Main Outcome Measures:

Change in IOP and AqCA from baseline during the WDT. Aqueous flow characteristics were also observed.

Results:

Peak IOP elevation above baseline was significantly higher in the glaucoma group, with an …