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The transition from planktonic to sessile mode of bacterial growth facilitates the survival in diverse environmental niches. Majority of bacterial infections involve biofilm formation. Pathogenic biofilms in hospital settings are linked to the survival and spread of pathogens among hospital patients and may result in increased hospitalization of patient. Since biofilms are difficult to eradicate through conventional antibiotic therapy, various strategies are applied to treat biofilm infection. Natural products including phytocompounds from medicinal plants have been reported as antibiofilm agent in the last decade. In this chapter a brief description on the role of biofilm in pathogenesis and their common control strategies have been illustrated followed by a recent update on the role of plant essential oils/phytocompounds as the promising antibiofilm agent. The probable mechanisms in controlling biofilm by phytocompounds are …