作者
Sujin Park, Kyung-Min Yang, Yuna Park, Eunji Hong, Chang Pyo Hong, Jinah Park, Kyoungwha Pang, Jihee Lee, Bora Park, Siyoung Lee, Haein An, Mi-Kyung Kwak, Junil Kim, Jin Muk Kang, Pyunggang Kim, Yang Xiao, Guangjun Nie, Akira Ooshima, Seong-Jin Kim
发表日期
2018/3
期刊
Journal of cancer prevention
卷号
23
期号
1
页码范围
1
出版商
Korean Society of Cancer Prevention
简介
Background
Smad3 linker phosphorylation plays essential roles in tumor progression and metastasis. We have previously reported that the mutation of Smad3 linker phosphorylation sites (Smad3-Erk/Pro-directed kinase site mutant constructs [EPSM]) markedly reduced the tumor progression while increasing the lung metastasis in breast cancer.
Methods
We performed high-throughput RNA-Sequencing of the human prostate cancer cell lines infected with adenoviral Smad3-EPSM to identify the genes regulated by Smad3-EPSM.
Results
In this study, we identified genes which are differentially regulated in the presence of Smad3-EPSM. We first confirmed that Smad3-EPSM strongly enhanced a capability of cell motility and invasiveness as well as the expression of epithelial-mesenchymal transition marker genes, CDH2, SNAI1, and ZEB1 in response to TGF-β1 in human pancreatic and prostate cancer cell lines. We …
学术搜索中的文章
S Park, KM Yang, Y Park, E Hong, CP Hong, J Park… - Journal of cancer prevention, 2018