作者
Anna Schultze, Alex J Walker, Brian MacKenna, Caroline E Morton, Krishnan Bhaskaran, Jeremy P Brown, Christopher T Rentsch, Elizabeth Williamson, Henry Drysdale, Richard Croker, Seb Bacon, William Hulme, Chris Bates, Helen J Curtis, Amir Mehrkar, David Evans, Peter Inglesby, Jonathan Cockburn, Helen I McDonald, Laurie Tomlinson, Rohini Mathur, Kevin Wing, Angel YS Wong, Harriet Forbes, John Parry, Frank Hester, Sam Harper, Stephen JW Evans, Jennifer Quint, Liam Smeeth, Ian J Douglas, Ben Goldacre
发表日期
2020/11/1
期刊
The Lancet Respiratory Medicine
卷号
8
期号
11
页码范围
1106-1120
出版商
Elsevier
简介
Background
Early descriptions of patients admitted to hospital during the COVID-19 pandemic showed a lower prevalence of asthma and chronic obstructive pulmonary disease (COPD) than would be expected for an acute respiratory disease like COVID-19, leading to speculation that inhaled corticosteroids (ICSs) might protect against infection with severe acute respiratory syndrome coronavirus 2 or the development of serious sequelae. We assessed the association between ICS and COVID-19-related death among people with COPD or asthma using linked electronic health records (EHRs) in England, UK.
Methods
In this observational study, we analysed patient-level data for people with COPD or asthma from primary care EHRs linked with death data from the Office of National Statistics using the OpenSAFELY platform. The index date (start of follow-up) for both cohorts was March 1, 2020; follow-up lasted until …
学术搜索中的文章
A Schultze, AJ Walker, B MacKenna, CE Morton… - The Lancet Respiratory Medicine, 2020